Angelman Syndrome is a neuro-genetic disorder related to developmental and intellectual delay.

Common symptoms include seizures, delayed motor skills, fine tremors, speech impediments, sudden jerky movements, sleep disturbance and a prevailing happy demeanor with frequent laughter.

Angelman Syndrome occurs as a result of genomic imprinting, where certain maternal genes are either deleted or become inactive. It can sometimes result from the mutation of a single gene.